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Livres
Articles (32)
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1

Home and Parental Influences on the Achievement of Lower Primary School Children in Singapore

Ling, Quah May, Sharpe, Pamela, Swee Eng, Audrey Lim, Heng, Mary Anne

Journal:

Singapore Journal of Education

Année:

1995

Langue:

english

Fichier:

PDF, 1.07 MB

english, 1995

2

Mini-review: discovery and development of platinum complexes designed to circumvent cisplatin resistance

Lloyd R. Kelland, Swee Y. Sharp, Ciaran F. O’Neill, Florence I. Raynaud, Philip J. Beale, Ian R. Judson

Journal:

Journal of Inorganic Biochemistry

Année:

1999

Langue:

english

Fichier:

PDF, 180 KB

english, 1999

3

Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease

Lynn Quek, Claire Sharpe, Neelanjana Dutt, Sue Height, Marlene Allman, Moji Awogbade, David C Rees, Mark Zuckerman, Swee Lay Thein

Journal:

British Journal of Haematology

Année:

2010

Langue:

english

Fichier:

PDF, 153 KB

english, 2010

4

Increased prevalence of renal cysts in patients with sickle cell disease

Meeks, Daveena, Navaratnarajah, Arunraj, Drasar, Emma, Jaffer, Ounali, Wilkins, C. Jason, Thein, Swee Lay, Sharpe, Claire C.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 908 KB

english, 2017

5

Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90

James E. H. Day, Swee Y. Sharp, Martin G. Rowlands, Wynne Aherne, Paul Workman, Christopher J. Moody

Journal:

Chemistry - A European Journal

Année:

2010

Langue:

english

Fichier:

PDF, 389 KB

english, 2010

6

Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies

Dr. James E. H. Day, Dr. Swee Y. Sharp, Dr. Martin G. Rowlands, Dr. Wynne Aherne, Dr. William Lewis, Dr. S. Mark Roe, Dr. Chrisostomos Prodromou, Prof. Dr. Laurence H. Pearl, Prof. Dr. Paul Workman, P

Journal:

Chemistry - A European Journal

Année:

2010

Langue:

english

Fichier:

PDF, 545 KB

english, 2010

7

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

Kwai-Ming J. Cheung, Thomas P. Matthews, Karen James, Martin G. Rowlands, Katherine J. Boxall, Swee Y. Sharp, Alison Maloney, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, G. Wynne Aherne, E

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 590 KB

english, 2005

8

Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol

Nicolas Proisy, Swee Y. Sharp, Kathy Boxall, Stephen Connelly, S. Mark Roe, Chrisostomos Prodromou, Alexandra M.Z. Slawin, Laurence H. Pearl, Paul Workman, Christopher J. Moody

Journal:

Chemistry & Biology

Année:

2006

Langue:

english

Fichier:

PDF, 788 KB

english, 2006

9

An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models

Udai Banerji, Nivedita Sain, Swee Y. Sharp, Melanie Valenti, Yasmin Asad, Ruth Ruddle, Florence Raynaud, Michael Walton, Suzanne A. Eccles, Ian Judson, Ann L. Jackman, Paul Workman

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2008

Langue:

english

Fichier:

PDF, 365 KB

english, 2008

10

Sickle cell nephropathy – a practical approach

Claire C. Sharpe, Swee L. Thein

Journal:

British Journal of Haematology

Année:

2011

Langue:

english

Fichier:

PDF, 459 KB

english, 2011

11

HSP90 inhibition: two-pronged exploitation of cancer dependencies

Jon Travers, Swee Sharp, Paul Workman

Journal:

Drug Discovery Today

Année:

2012

Langue:

english

Fichier:

PDF, 907 KB

english, 2012

12

Enhancing multipoint desktop video conferencing (MDVC) with lesson video clips: recent developments in pre-service teaching practice in Singapore

Leslie Sharpe, Chun Hu, Lachlan Crawford, Saravanan Gopinathan, Myint Swe Khine, Swee Ngoh Moo, Angela Wong

Journal:

Teaching and Teacher Education

Année:

2003

Langue:

english

Fichier:

PDF, 260 KB

english, 2003

13

The Association of CCND1 Overexpression and Cisplatin Resistance in Testicular Germ Cell Tumors and Other Cancers

Elodie E. Noel, Marc Yeste-Velasco, Xueying Mao, Jackie Perry, Sakunthala C. Kudahetti, Ningfeng F. Li, Swee Sharp, Tracy Chaplin, Liyan Xue, Alan McIntyre, Ling Shan, Thomas Powles, R. Tim D. Oliver,

Journal:

The American Journal of Pathology

Année:

2010

Langue:

english

Fichier:

PDF, 585 KB

english, 2010

14

Selective potentiation of platinum drug cytotoxicity in cisplatin-sensitive and-resistant human ovarian carcinoma cell lines by amphotericin B

Sharp, Swee Y., Mistry, Prakash, Valenti, Melanie R., Bryant, Alex P., Kelland, Lloyd R.

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1994

Langue:

english

Fichier:

PDF, 766 KB

english, 1994

15

Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy

Loreta M Rodrigues, Yuen-Li Chung, Nada M S Al Saffar, Swee Y Sharp, Laura E Jackson, Udai Banerji, Marion Stubbs, Martin O Leach, John R Griffiths, Paul Workman

Journal:

BMC Research Notes

Année:

2012

Langue:

english

Fichier:

PDF, 411 KB

english, 2012

16

[Advances in Cancer Research] Volume 95 || Inhibitors of the HSP90 Molecular Chaperone: Current Status

Année:

2006

Langue:

english

Fichier:

PDF, 435 KB

english, 2006

17

Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies

Day, James E. H., Sharp, Swee Y., Rowlands, Martin G., Aherne, Wynne, Hayes, Angela, Raynaud, Florence I., Lewis, William, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Workman, Paul, Moo

Journal:

ACS Chemical Biology

Année:

2011

Langue:

english

Fichier:

PDF, 4.69 MB

english, 2011

18

Cancer Drug Design and Discovery || Exploiting Cancer Dependence on Molecular Chaperones

Année:

2014

Langue:

english

Fichier:

PDF, 2.81 MB

english, 2014

19

Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin

McErlean, Christopher S. P., Proisy, Nicolas, Davis, Christopher J., Boland, Nicola A., Sharp, Swee Y., Boxall, Kathy, Slawin, Alexandra M. Z., Workman, Paul, Moody, Christopher J.

Journal:

Organic & Biomolecular Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 515 KB

english, 2007

20

Using lesson video clips via multipoint desktop video conferencing to facilitate reflective practice

Hu, Chun, Sharpe, Leslie, Crawford, Lachlan, Gopinathan, Saravanan, Khine, Myint Swe, Moo, Swee Ngoh, Wong, Angela

Journal:

Journal of Information Technology for Teacher Education

Année:

2000

Langue:

english

Fichier:

PDF, 114 KB

english, 2000

21

Solid-Phase Immunoassays in Mechanism-Based Drug Discovery: Their Application in the Development of Inhibitors of the Molecular Chaperone Heat-Shock Protein 90

Hardcastle, Anthea, Boxall, Kathy, Richards, Juliet, Tomlin, Peter, Sharp, Swee, Clarke, Paul, Workman, Paul, Aherne, Wynne

Journal:

Assay and Drug Development Technologies

Année:

2005

Langue:

english

Fichier:

PDF, 242 KB

english, 2005

22

Multipoint Desktop Video Conferencing in Teacher Education: Preliminaries, problems and progress

Crawford, Lachlan, Sharpe, Leslie, Chun, Hu, Gopinathan, S., Ngoh, Moo Swee, Wong, Angela

Journal:

Asia-Pacific Journal of Teacher Education

Année:

2002

Langue:

english

Fichier:

PDF, 144 KB

english, 2002

23

Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines

Patel, Alpa, Sharp, Swee Y., Hall, Katelan, Lewis, William, Stevens, Malcolm F. G., Workman, Paul, Moody, Christopher J.

Journal:

Organic & Biomolecular Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2016

24

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Cheeseman, Matthew D., Chessum, Nicola E. A., Rye, Carl S, Pasqua, A Elisa, Tucker, Michael J, Wilding, Birgit, Evans, Lindsay E, Lepri, Susan, Richards, Meirion, Sharp, Swee Y., Ali, Salyha, Rowlands

Journal:

Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 3.79 MB

english, 2016

25

Molecular profiling and combinatorial activity of CCT068127: A potent CDK2 and CDK9 inhibitor

Whittaker, Steven R., Barlow, Clare, Martin, Mathew P., Mancusi, Caterina, Wagner, Steve, Self, Annette, Barrie, Elaine, te Poele, Robert, Sharp, Swee, Brown, Nathan, Wilson, Stuart, Jackson, Wayne, F

Journal:

Molecular Oncology

Année:

2017

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2017

26

Demonstrating In-Cell Target Engagement using a Pirin Protein Degradation Probe (CCT367766)

Chessum, Nicola E. A., Sharp, Swee Y., Caldwell, John J, Pasqua, A Elisa, Wilding, Birgit, Colombano, Giampiero, Collins, Ian, Ozer, Bugra, Richards, Meirion, Rowlands, Martin G., Stubbs, Mark, Burke,

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 2.24 MB

english, 2017

27

Indispensable Amino Acid–Deficient Diets Induce Seizures in Ketogenic Diet–Fed Rodents, Demonstrating a Role for Amino Acid Balance in Dietary Treatments for Epilepsy

Gietzen, Dorothy W, Lindström, Sarah H, Sharp, James W, Teh, Pok Swee, Donovan, Michael J

Journal:

Journal of Nutrition

Année:

2018

Langue:

english

Fichier:

PDF, 1.99 MB

english, 2018

28

Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models

Banerji, Udai, Sain, Nivedita, Sharp, Swee Y., Valenti, Melanie, Asad, Yasmin, Ruddle, Ruth, Raynaud, Florence, Walton, Michael, Eccles, Suzanne A., Judson, Ian, Jackman, Ann L., Workman, Paul

Journal:

Cancer Chemotherapy and Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 633 KB

english, 2018

29

Correction: In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors

Sharp, Swee Y., Boxall, Kathy, Rowlands, Martin, Prodromou, Chrisostomos, Roe, S. Mark, Maloney, Alison, Powers, Marissa, Clarke, Paul A., Box, Gary, Sanderson, Sharon, Patterson, Lisa, Matthews, Thom

Journal:

Cancer Research

Année:

2019

Langue:

english

Fichier:

PDF, 182 KB

english, 2019

30

Correction: Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin

Holmes, Joanna L., Sharp, Swee Y., Hobbs, Steve, Workman, Paul

Journal:

Cancer Research

Année:

2019

Langue:

english

Fichier:

PDF, 177 KB

english, 2019

31

Establishment of an Isogenic Human Colon Tumor Model for NQO1 Gene Expression: Application to Investigate the Role of DT-Diaphorase in Bioreductive Drug Activation In Vitro and In Vivo

Sharp, Swee Y., Kelland, Lloyd R., Valenti, Melanie R., Brunton, Lisa A., Hobbs, Steve, Workman, Paul

Journal:

Molecular Pharmacology

Année:

2000

Fichier:

PDF, 207 KB

2000

32

Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches

Darby, John F., Vidler, Lewis R., Simpson, Peter J., Al-Lazikani, Bissan, Matthews, Stephen J., Sharp, Swee Y., Pearl, Laurence H., Hoelder, Swen, Workman, Paul

Journal:

Scientific Reports

Année:

2020

Fichier:

PDF, 4.14 MB

2020